Resveratrol & Melanoma

Cancer is perhaps, the most dynamic area of resveratrol research. Resveratrol is the first natural medicinal to have solid evidence behind it showing that it blocks or stops many stages of cancer. Resveratrol not only prevents cancer, it’s being proposed as an additional treatment. The number of studies has exploded in the past three years, with the depth of knowledge about this polyphenol increasing with each report. Resveratrol is a broad-spectrum agent that stops cancer in many diverse ways, from blocking estrogen and androgens to modulating genes. Some of the latest information reveals that resveratrol causes a unique type of cell death (cell apoptosis), and kills cancer cells whether they do or do not have the tumor suppressor gene, it also works whether cancer cells are estrogen receptor-positive or negative. Researchers in Austria have done elaborate studies showing that resveratrol blocks the ability of cancer cells to metastasize to bone (30-71%). [20] Effective in-vitro research results were reported for pancreas, breast, renal, prostate and colon cancers. All research with human-derived tumors are conducted in-vitro or in life extension research terms, ex-vivo. This means the tumor cells of a specific type of human cancer are grown in cell culture and compounds such as resveratrol are studied to determine the effectiveness in cell killing activity (cell apoptosis). In vitro refers to the cell culture techniques and ex-vivo refers to human cancer cell lines being used for the investigational research study.Resveratrol also acts against a component of Western diet that promotes cancer cell growth: linoleic acid. Linoleic acid is converted to arachidonic, which is converted to hormone-like substances (such as prostaglandin E2 and leukotriene B4) that can promote inflammatory processes that stimulate cancer cell growth, among other things. Resveratrol specifically inhibits the enzyme cyclooxygenase-2 (COX-2) to reverse inflammation. It has been demonstrated that the western diet can cause colon cancer in rodents without any other chemical or factor being necessary. In a study from Japan, resveratrol in an amount easily obtained by supplementation, inhibited the growth of breast cancer cells, and blocked the growth-promoting effects of linoleic acid from the Western diet. Resveratrol works against a wide range of cancers Both at the preventive and treatment stages. Its ability to stop cancer is connected to its capability, first, to distinguish a cancer cell from a normal cell. Unlike chemotherapeutic drugs that affect normal as well as cancer cells, resveratrol does not damage healthy cells. Not only is it not harmful to normal cells, it protects them. Second, resveratrol is sophisticated in its actions. It doesn’t just scavenge free radicals; it activates and deactivates critical enzymes and genes, hormones and chemicals. Cancers Inhibited by Resveratrol According to published research*Colon, Neuroblastoma, Esophageal, Breast (all types), Prostate (all types), Leukemia (various types), Non-Hodgkins Lymphoma, Metastasis to bone, Skin, Pancreas, Ovarian, Melanoma, Liver, Lung,Stomach, Oral, Cervical, Lymphoma (various types), Thyroid. *In laboratory animals and cell culture studies.
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